Summary

Targeting undruggable proteins with significant clinical value, IADDP integrates multiple proprietary techniques to identify possible allosteric sites, uncover potential allosteric mechanisms, design novel allosteric molecules, and achieve the mission of “drugging the undruggable”

Accelerating Early-Stage Allosteric Drug Discovery

Unveiling allosteric mechanisms

Identify allosteric binding sites, link binding and function and address allosteric regulation with sophisticated experimental and computational techniques.

Allosteric molecule discovery

Combining a variety of screening techniques and rational designs, the platform centers on potential allosteric sites to discover small molecules that induce protein allostery

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Supporting different preclinical stages

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  • Protein insights
  • Hits screening
  • Structural optimization
  • Allosteric mechanism
  • Understand the relationship between the conformation and function of target proteins. Discover the core sites of target proteins via multiple methods, including gene editing, macromolecular nuclear magnetic resonance (NMR), and molecular simulation.
  • Explore chemical spaces. Practical screens of virtual libraries and our “in-house” library through computer and AI-assisted methods.
  • Molecular optimization for better druggability. Perform iterative design and provide allosteric modulators through integrated medicinal chemistry and pharmacological evaluation.
  • Characterize allosteric sites with precision. Verify structural information of defined allosteric sites using X-ray crystallography, biophysical and biochemical methods, and then use the structural information as the basis to guide the discovery of allosteric modulators.

Click Pipeline to learn more about the products available from the platform.

Platform & Pipeline

Partnership